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Clindamycin-benzoyl peroxide gel is a prescription topical medication used to treat acne vulgaris. It combines clindamycin (an antibiotic) with benzoyl peroxide (which helps reduce acne-causing bacteria and unclog pores) in one formulation and is applied directly to the skin.
This treatment is available in different strengths, including 1%/5%, 1.2%/5% and 1.2%/3.75%. The difference lies in the concentration of the active ingredients, which affects how strongly the treatment works. Higher concentrations provide a more intensive treatment, while lower concentrations offer a milder approach.
A licensed healthcare provider will determine the most appropriate formulation and strength based on your individual skin type, medical history, and the severity of your condition.
Clindamycin-benzoyl perox gel is used on the skin, usually twice daily in the morning and evening, or as directed by your physician. Before applying it, the skin should be gently washed, rinsed with warm water, and patted dry.
This medicine is for dermatologic use only and should not be used in the eyes or on internal surfaces. Using it consistently and only as directed can help support treatment while lowering the chance of unnecessary irritation.
The most common side effects with Clindamycin-benzoyl perox gel are skin-related and happen where the medicine is applied. These can include dryness, itching, peeling, redness, sunburn, or other application-site reactions.
Although this is a topical product, there are also important safety concerns to know about. Stop using the gel and contact your provider right away if you develop severe diarrhea, bloody diarrhea, or strong stomach cramps. Seek urgent medical help if you have signs of a serious allergic reaction, such as swelling, trouble breathing, or other severe symptoms.
*Prescription products require an online consultation with a licensed healthcare provider who will determine if treatment is appropriate. Individual results may vary.
Answer a few health questions online – your information will be reviewed by a licensed provider.
If appropriate, a doctor will issue a prescription. Treatment decisions are always made by the provider.
Your medication is shipped from a licensed partner pharmacy and typically arrives in 1–2 business days.
*Prescription products require an online consultation with a licensed healthcare provider who will determine if treatment is appropriate. Images are for Illustration purposes only. Actual product and packaging may differ.
This prescription gel is used for the treatment of acne vulgaris and is typically recommended when a provider determines that a combination topical therapy is appropriate. Because it contains both clindamycin and benzoyl peroxide, a clinical review helps confirm that this approach fits your skin condition and medical history.
If you have a history of certain gastrointestinal conditions or prior reactions to similar products, your provider may recommend a different option.
This gel is generally applied twice daily, in the morning and evening, after gently cleansing the skin. Consistent use as directed is important, and applying more than recommended can increase the risk of irritation without improving outcomes.
If you are unsure how to integrate this into your routine, your provider can help adjust your regimen to reduce irritation.
This gel is designed to treat acne as part of a consistent routine. It is not intended as a one-time or spot treatment, and results can vary depending on your skin and how you use it.
If your acne does not improve or your skin becomes difficult to manage, your provider may adjust your treatment plan.
Certain symptoms require prompt attention. Although this is a topical treatment, the PI warns about serious gastrointestinal effects and allergic reactions that should not be ignored.
There are several things to avoid during treatment to reduce the risk of irritation or unwanted reactions. The PI highlights sunlight exposure and certain product combinations as key concerns.
Some products can increase irritation or reduce effectiveness when used together. The PI specifically warns about combining certain topical treatments.
A few simple habits can make a big difference in how your skin responds to treatment. These steps focus on reducing irritation and supporting consistent use.
This medication has specific storage instructions, especially after it has been prepared or dispensed. Following these instructions helps maintain its stability and effectiveness.
You should be careful when combining this gel with other acne treatments. Using multiple products at the same time can increase skin irritation, especially if they contain strong or drying ingredients.
If your skin becomes more irritated after adding another product, stop the additional treatment and consult your provider.
No, this gel should only be used on external skin areas. Sensitive areas like the eyes, inside the nose, and mouth can react strongly if exposed.
If irritation continues after accidental contact, contact your provider for further advice.
This medication can make your skin more sensitive to sunlight, so extra care is needed if you are frequently outdoors or use tanning beds.
Yes, protecting your skin from sunlight is an important part of using this medication. Your skin may react more strongly to sun exposure during treatment.
Taking these steps can help reduce the risk of sunburn or irritation while using the gel.
Skin reactions can happen, especially when starting treatment. If symptoms are mild, your provider may suggest adjusting how often you use the gel or simplifying your routine.
If irritation becomes severe or does not improve, seek medical advice or call 911 when it’s a emergency.
These may be signs of a serious allergic reaction and require immediate medical attention. Do not continue using the medication.
Prompt treatment is important to reduce the risk of complications.
This medication may not be appropriate if you have a history of certain bowel conditions. It’s important to discuss your medical history before starting treatment.
If you develop symptoms like severe diarrhea, stop use and seek care.
No, you should not use this medication if you have a known allergy to lincomycin or any of its components. This could increase the risk of a serious reaction.
If you experience symptoms after use, stop immediately and seek care.
No, this medication should only be used for the condition your provider prescribed it for. Using it for other skin concerns may not be appropriate and could increase the risk of side effects.
If you think you need a different treatment, speak with your provider.
This medication has a limited shelf life after it is prepared. Using it beyond that time may reduce effectiveness.
If your medication has expired, contact your provider or pharmacy for next steps.
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Clindamycin Phosphate and Benzoyl Peroxide Gel 1%/5% – combination topical antibiotic therapy for inflammatory acne vulgaris, reducing bacteria, inflammation, and clogged pores. / Source: NCBI
Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=76795d1b-e1f2-4d1d-b42a-f1d4448c63c0 / Published: March 21, 2024
As a medical expert, Igde, MD has carefully reviewed the medical content on this page and confirmed that it is accurate and up to date with current medical knowledge.
For more information about the scope of the reviewed content and the role of our medical advisors, please visit our Medical Board page.
Last Update on 02/29/2026 | Next Information check will be on 08/29/2026
*All information presented on this page is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment. Prescription products are available only after an online consultation with a licensed U.S. healthcare provider who determines if treatment is appropriate. Individual results may vary. US Quick Health LLC does not sell or ship medications directly. All prescriptions are fulfilled by licensed U.S. pharmacies.
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All trademarks and registered brand names are the property of their respective owners. US Quick Health is a telehealth coordination platform and does not operate as a pharmacy. No medications or medical products are directly sold or shipped by US Quick Health. All information provided on usquickhealth.com is for informational purposes only and does not constitute medical advice or a binding offer. Use of this platform is at your own risk and initiative. You are solely responsible for complying with the applicable laws in your jurisdiction. Our services are not intended for emergency medical situations. In case of an emergency, please dial 911.
Medical consultations are conducted by independent, licensed healthcare professionals. US Quick Health does not employ medical providers and does not interfere with clinical decisions. US Quick Health complies with HIPAA and ensures that all personal health information (PHI) is handled securely and in accordance with U.S. privacy laws. All prescriptions are fulfilled by licensed U.S. pharmacies. Company Name: US Quick Health, LLC | Business Address: STE 27345 W Sand Lake Rd, Suite 210, Office 2630, Orlando, FL 32819 | Support Email: [email protected] | General Inquiries: [email protected] | Phone: +1 (332) 223-0323 | Business Hours: 24/7
© 2025 US Quick Health, LLC. All rights reserved.
All trademarks and registered brand names are the property of their respective owners. US Quick Health is a telehealth coordination platform and does not operate as a pharmacy. No medications or medical products are directly sold or shipped by US Quick Health. All information provided on usquickhealth.com is for informational purposes only and does not constitute medical advice or a binding offer. Use of this platform is at your own risk and initiative. You are solely responsible for complying with the applicable laws in your jurisdiction. Our services are not intended for emergency medical situations. In case of an emergency, please dial 911.
Medical consultations are conducted by independent, licensed healthcare professionals. US Quick Health does not employ medical providers and does not interfere with clinical decisions. US Quick Health complies with HIPAA and ensures that all personal health information (PHI) is handled securely and in accordance with U.S. privacy laws. All prescriptions are fulfilled by licensed U.S. pharmacies. Company Name: US Quick Health, LLC | Business Address: STE 27345 W Sand Lake Rd, Suite 210, Office 2630, Orlando, FL 32819 | Support Email: [email protected] | General Inquiries: [email protected] | Phone: +1 (332) 223-0323 | Business Hours: 24/7
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