Fluticasone And Salmeterol Diskus Inhaler

Generic for Advair Diskus InhalerAsthma Treatment

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What is Fluticasone and Salmeterol Diskus Inhaler?

Fluticasone and Salmeterol Diskus Inhaler is a prescription combination inhaler used for asthma control in patients 4 years of age and older. It contains two medicines: fluticasone propionate, an inhaled corticosteroid, and salmeterol, a long-acting beta2-agonist.

  • Generic for Advair® Diskus
  • Supplied as an inhalation powder in a Diskus dry powder inhaler
  • Available on this page in 100/50 mcg, 250/50 mcg, and 500/50 mcg strengths
  • Used as a scheduled asthma control medication
  • Not used for sudden breathing symptoms or acute bronchospasm

A licensed provider can review your asthma history, current treatment, and safety factors to decide whether this inhaler may be appropriate.

How do I use Fluticasone and Salmeterol Diskus Inhaler?

Fluticasone and Salmeterol Diskus Inhaler is inhaled by mouth using the Diskus inhaler. It is typically used as 1 inhalation twice daily, about 12 hours apart, exactly as prescribed by your healthcare provider.

  • Rinse your mouth with water after each use and spit it out
  • Do not use it for sudden asthma symptoms or as rescue treatment
  • Use rescue medicine for quick relief if your provider has prescribed it
  • Do not use it with other medicines that contain a long-acting beta2-agonist unless your provider tells you to
  • Do not change your dose or stop treatment without provider guidance

Response can vary, and maximum benefit may take 1 week or longer.

What are the possible side effects?

Fluticasone and Salmeterol Diskus Inhaler can cause side effects. Some common side effects in asthma patients may include upper respiratory tract infection or inflammation, sore throat, voice changes, oral thrush, bronchitis, cough, headache, nausea, or vomiting.

  • Rinsing your mouth after use can help lower the chance of a fungal infection in the mouth or throat
  • Contact your provider if your asthma worsens or your rescue medicine does not work as well
  • Seek urgent care for severe allergic symptoms, sudden worsening breathing, or wheezing right after use
  • Tell your provider about milk protein allergy, heart problems, high blood pressure, seizures, thyroid problems, diabetes, infections, eye problems, weak bones, pregnancy, or breastfeeding
  • Children using inhaled corticosteroids may need growth monitoring

See Important Safety Information and full Prescribing Information.

*Prescription products require an online consultation with a licensed healthcare provider who will determine if treatment is appropriate. Fluticasone propionate and salmeterol are the active ingredients in Fluticasone and Salmeterol Diskus Inhaler, a generic alternative to Advair Diskus®. Advair Diskus® is a registered trademark of its respective owner and is mentioned for reference only. Individual results may vary.

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Important safety information

FAQ

Is Fluticasone and Salmeterol Diskus Inhaler used for daily asthma control?

Fluticasone and Salmeterol Diskus Inhaler is used as a scheduled asthma control inhaler for patients 4 years of age and older. It combines an inhaled corticosteroid with a long-acting bronchodilator.

It is not for sudden breathing symptoms. A licensed provider will review your asthma history, current medicines, symptom control, and safety factors before deciding whether this inhaler may be appropriate.

What should I tell the provider before using Fluticasone and Salmeterol Diskus Inhaler?

Tell the provider about any allergy to milk proteins, fluticasone, salmeterol, or inhaler ingredients. Also mention heart problems, high blood pressure, seizures, thyroid problems, diabetes, infections, tuberculosis history or exposure, eye problems, weak bones, liver problems, pregnancy, or breastfeeding.

Share all medicines you use, especially other LABA-containing inhalers, ritonavir, ketoconazole, MAO inhibitors, tricyclic antidepressants, beta-blockers, or diuretics.

Do I need a prescription to get Fluticasone and Salmeterol Diskus Inhaler online?

Yes. Fluticasone and Salmeterol Diskus Inhaler requires a prescription. Online access still starts with a licensed provider reviewing your health information.

If treatment is appropriate, the provider may prescribe it for pharmacy fulfillment. If it is not appropriate, they may recommend another next step based on your asthma needs and medical history.

Can I use Fluticasone and Salmeterol Diskus Inhaler during an asthma attack?

No. Fluticasone and Salmeterol Diskus Inhaler is not for sudden asthma symptoms or acute bronchospasm.

Use your rescue medicine as directed by your provider. Seek urgent medical help if your breathing symptoms are severe, getting worse, or not improving with your usual rescue treatment.

Why should I rinse my mouth after using it?

Rinse your mouth with water and spit it out after each use. This helps lower the chance of getting a fungal infection in the mouth or throat.

Contact your provider if you notice white patches, soreness, irritation, or other unusual mouth or throat symptoms while using this inhaler.

Can I use another LABA inhaler with Fluticasone and Salmeterol Diskus Inhaler?

Do not use Fluticasone and Salmeterol Diskus Inhaler with another medicine that contains a long-acting beta2-agonist unless your provider specifically tells you to.

Using more than one LABA medicine can increase safety risks. Share all inhalers, nebulizer medicines, and asthma medications during your consultation.

Can I use Fluticasone and Salmeterol Diskus Inhaler if I have a milk protein allergy?

You should not use Fluticasone and Salmeterol Diskus Inhaler if you have a severe allergy to milk proteins. Diskus dry powder inhalers can contain ingredients that make this allergy important to discuss before treatment.

Tell the provider about any past allergic reactions to inhalers, medicines, milk proteins, or other ingredients.

For full safety details, see Important Safety / prescribing Information.

Other Asthma treatments

Sources

References

ADVAIR DISKUS - prescribing information referenced for fluticasone propionate and salmeterol inhalation powder, the active ingredients in Fluticasone and Salmeterol Diskus Inhaler. / Source: DailyMed Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cf306656-0d4c-4edd-9d6a-3471f99484e6 / Published: April 26, 2026

Medically reviewed by

H. Igde - MD

Clinical Expertise: Anesthesiology, Emergency Medicine, Urology, and Oncology

Dr. Igde reviewed the medical information on this page for accuracy against current medical knowledge. This is an editorial, non-clinical review: it is not medical advice and does not create a doctor-patient relationship. Whether a treatment is appropriate for you is decided by an independent U.S. licensed provider.

For more information about the scope of the reviewed content and the role of our medical advisors, please visit our Medical Board page.

H. Igde - MD
Last updated on 02/28/2026Next information check will be on 01/29/2027

*All information presented on this page is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment. Prescription products are available only after an online consultation with a licensed U.S. healthcare provider who determines if treatment is appropriate. Individual results may vary. US Quick Health LLC does not sell or ship medications directly. All prescriptions are fulfilled by licensed U.S. pharmacies.

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