Nucala

Nucala® is a prescription biologic used as an add-on treatment for severe asthma linked to high levels of eosinophils (a type of white blood cell). It’s designed for people whose asthma is not well controlled with standard inhalers. Nucala® is used regularly to help manage symptoms over time - not for sudden breathing problems.

• Approved for adults and children 6 years and older
• Used for severe eosinophilic asthma
• Belongs to a class called IL-5 antagonist biologics
• Added to existing asthma medications
• Given as an injection under the skin

Nucala® is given as a subcutaneous injection (under the skin) on a regular schedule, usually every few weeks. The exact timing and setup depend on your treatment plan and how your provider prescribes it.

• Injected under the skin using a vial or device
• Given on a fixed schedule (not as needed)
• Typically administered every 4 weeks
• May be given in a clinic or at home after training
• Not used for asthma attacks

Follow your provider’s instructions carefully and continue your other asthma medications unless told otherwise.

Nucala® can cause side effects, although not everyone experiences them. Some are general and manageable, while others may require medical attention.

• Headache or fatigue
• Injection-site reactions (redness, swelling, discomfort)
• Back pain or general aches
• Cold-like symptoms
• Feeling unwell

Seek urgent medical help if you notice signs of a serious allergic reaction, such as swelling of the face or throat, trouble breathing, or severe rash. Contact your provider if you experience ongoing or unusual symptoms during treatment.

For detailed information refer to the Important Safety / Prescribing Information.

Proper storage and handling help maintain the effectiveness and safety of Nucala®.

• Follow instructions on the medication label
• Store as directed (often refrigerated - confirm packaging)
• Do not use expired or damaged medication
• Keep out of reach of children
• Ask your pharmacist if unsure

If you have questions about storage, your provider or pharmacist can help.

Nucala® is usually added to your existing asthma treatment rather than replacing it. It’s prescribed when inhalers alone are not enough to control symptoms.

• Typically used with inhaled medications
• Part of a long-term treatment plan
• Not a first-line standalone therapy
• Your provider may adjust your full regimen

Do not stop your current asthma medications unless your provider tells you to.

No, Nucala® is not used to treat asthma attacks. It works over time and does not provide immediate relief.

• Not a rescue medication
• Does not act quickly for symptoms
• Keep your rescue inhaler available
• Follow your asthma action plan

If you have severe or sudden breathing problems, seek medical care right away.

Before starting Nucala®, your provider may perform tests to confirm that it matches your type of asthma.

• Blood test to check eosinophil levels
• Review of your symptoms and history
• Assessment of current medications
• Evaluation of asthma control

These steps help ensure the treatment is appropriate for your condition.

If you miss a scheduled dose, contact your provider or clinic as soon as possible to reschedule.

• Do not take an extra dose on your own
• Try to stay on your regular schedule
• Ask your provider how to proceed
• Keep track of your appointments

Your provider will guide you on how to safely continue treatment.

No, you should not change your dosing schedule without medical advice. The timing is based on your individual treatment plan.

• Schedule is personalized
• Changes may affect consistency
• Always follow provider instructions
• Ask before making adjustments

If your schedule becomes difficult, talk to your provider about possible solutions.

You should not stop steroid medications on your own. Any changes need to be carefully managed by your provider.

• Sudden stopping can worsen asthma
• Reductions are usually gradual
• Nucala® does not replace steroids immediately
• Follow provider guidance

Always consult your provider before making changes to your treatment.

There are no specific restrictions listed for alcohol use with Nucala®, but it’s still important to monitor how you feel.

• No direct interaction noted
• Alcohol may affect your overall health
• Watch for any unusual symptoms
• Ask your provider if unsure

Most people can continue normal activities after an injection, including driving. However, your reaction may vary.

• Monitor how you feel after treatment
• Avoid driving if you feel unwell
• Watch for dizziness or fatigue
• Safety comes first

If you’re unsure, wait until you feel stable before driving.

Nucala® is injected under the skin in specific areas of the body. Your provider will guide you on proper technique.

• Common areas include the thigh, abdomen, or upper arm
• Injection sites may be rotated
• Given subcutaneously (under the skin)
• Follow provider instructions

Some patients may be able to administer Nucala® at home after proper training, depending on their situation.

• Initial doses may be given in a clinic
• Training is required for self-injection
• Not suitable for every patient
• Follow provider guidance

Your provider will determine if home use is appropriate for you.

Before starting Nucala®, share important health information with your provider to ensure safe treatment.

• History of allergic reactions
• Current medications or supplements
• Pregnancy or breastfeeding status
• Any ongoing health conditions
• Past reactions to similar treatments

Providing complete information helps your provider make the best decision for your care.

Nucala® (Mepolizumab) Injection - Add-on maintenance treatment for severe eosinophilic asthma. / Source: NCBI Link: https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=mepolizumab